Get in Bed with PLUS!

PLUS launches 2 new sleep gummies to help you fall asleep, stay asleep, and wake up refreshed.

It’s reported that 1 in 5 adults in the United States suffers from a sleep disorder (Ford et al., 2015). So it’s not surprising that one of the top products people look for when they walk into a dispensary is something to help them sleep.

Using the latest, cutting-edge science, PLUS dreamed up two new gummies to help people solve that challenge. Recent research highlights the interplay between cannabis, our endocannabinoid system, and our body’s natural circadian rhythm (Hodges et al., 2019; Antony et al., 2020; Hanlon et al., 2020). Guided by the latest findings, we crafted two new Sleep gummies with specific chemistry precisely designed to promote a restful, well-rounded night of sleep.

Three components of a great night of sleep are falling asleep quickly, staying asleep longer, and waking up feeling refreshed (Am Psych Assoc, 2013). To make sure our gummies effectively addressed each one of these components, we crafted a blend of three cannabinoids (THC, CBN, and CBD), combined with a physiologic dose of melatonin, to create a product that would address each of these components and provide a well-rounded night of sleep (Carlini et al., 1981; Zhdanova et al., 2001; Nicholson et al., 2004; Ferracioli-Oda et al., 2018; Hergenrather et al., 2020).

cannabis and covid 19 Research

Each cannabinoid was selected for the particular roles it plays in promoting better sleep, but together they are greater than the sum of their parts, a synergistic result known as the entourage effect. We also included a low dose (0.5mg) of melatonin to support our bodies’ circadian rhythm, so these gummies actually work in concert with our natural systems (Dollins et al., 1994). Simply said, your body doesn’t need as much melatonin as you might think; products that you find in drugstores have a much higher dose, which is like using a sledgehammer to crack a nut.

We at PLUS are proud to introduce two new Sleep products. Why two? We know there are different types of cannabis users, those who are more experienced with a higher tolerance for THC, and those who are just getting started. We also know there is a range of issues that cause difficulty sleeping, and our products are designed to give consumers the option to tailor their experience to their specific needs. Like all PLUS products, these gummies are handmade by our team of experts in our state-of-the-art manufacturing facility. We also wanted to make a healthier sleep-focused edible that would be great for bedtime, so our products use all-natural flavors and colors, and are low in sugar and calories, with only 0.7g of sugar and 5 calories per piece.

Meet the lineup:

● PLUS Sleep Cloudberry: With a higher THC to CBD and CBN ratio for a greater psychoactive effect, Sleep Cloudberry is ideal for more experienced users. The 5mg THC to 1mg CBN to 1mg CBD ratio can help soothe the aches and pains that may interfere with a restful night of sleep.

● PLUS CBNRelief Lychee: A higher CBD and CBN to THC ratio, CBNRelief Lychee is great for newer or therapeutic cannabis users. With 1mg THC, 2mg of CBN, and 3mg of CBD, this gummy may help calm a racing mind from everyday stress and anxiety to help you drift off more easily.

References:

American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. Washington, DC: American Psychiatric Association, 2013.

Antony JM, McDonald AC, Noorbakhsh F, Guthrie N, Evans M. Changing the Tone of Clinical Study Design in the Cannabis Industry. Transl Neurosci. 2020;11:4-9.

Carlini EA, Cunha JM. Hypnotic and antiepileptic effects of cannabidiol. J Clin Pharmacol. 1981;21(S1):417S-427S.

Dollins AB, Zhdanova IV, Wurtman RJ, Lynch HJ, Deng MH. Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance. Proc Natl Acad Sci U S A. 1994;91(5):1824-1828.

Ferracioli-Oda E, Qawasmi A, Bloch MH. Meta-Analysis: Melatonin for the Treatment of Primary Sleep Disorders. Focus (Am Psychiatr Publ). 2018;16(1):113-118.

Ford ES, Cunningham TJ, Croft JB. Trends in Self-Reported Sleep Duration among US Adults from 1985 to 2012. Sleep. 2015;38(5):829-832.

Hanlon EC. Impact of circadian rhythmicity and sleep restriction on circulating endocannabinoid (eCB) N-arachidonoylethanolamine (anandamide). Psychoneuroendocrinology. 2020;111:104471.

Hergenrather JY, Aviram J, Vysotski Y, Campisi-Pinto S, Lewitus GM, Meiri D. Cannabinoid and Terpenoid Doses are Associated with Adult ADHD Status of Medical Cannabis Patients. Rambam Maimonides Med J. 2020;11(1):e0001.

Hodges EL, Ashpole NM. Aging circadian rhythms and cannabinoids. Neurobiol Aging. 2019;79:110-118.

Nicholson AN, Turner C, Stone BM, Robson PJ. Effect of Delta-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults. J Clin Psychopharmacol. 2004;24(3):305-313.

Zhdanova IV, Wurtman RJ, Regan MM, Taylor JA, Shi JP, Leclair OU. Melatonin treatment for age-related insomnia. J Clin Endocrinol Metab. 2001;86(10):4727-4730.

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